Zapraszamy na pierwszy w 2016 roku koncert hiphopowy w Chojnicach!
Bilety (dostępne od czwartku 21 stycznia):
I PULA: 25 zł
II PULA: 30 zł
w dniu koncertu: 35 zł
w Cynamon Clubie oraz na stacji paliw CANPOL
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phosphates directly bind to neurofilament light chain (NF L) for the regulation of NF L self assembly Sung Kuk Kim1, Ho Kim1, Yong Ryoul Yang2, Pann Ghill Suh2 and Jong Soo Chang1Accepted 17 February 2011Accepted article preview online Authentic White Jacob Larsson Jersey 22 February 2011 Top of pageAbstractPhosphatidylinositol phosphates (PtdInsPs) are ubiquitous membrane phospholipids that play diverse roles in cell growth and differentiation. To clarify the regulation mechanism acting on neurofilament light chain (NF L) self assembly, we examined the effects of various PtdInsPs on this process. We found that PtdInsPs, including PI(4,5)P2, directly bind to the positively charged Arg54 of murine NF L, and this binding promotes NF L self assembly in vitro. Mutant NF L (R53A/R54A) proteins lacking binding affinity to PtdInsPs did not have the same effect, but the mutant NF L proteins showed greater self assembly than the wild type in the absence of any PtdInsP. These results collectively suggest that Arg54 plays a pivotal role in NF L self assembly